Located above the navel, Manipura translates from Sanskrit as "city of jewels" alternatively translated as "resplendent gem" or "lustrous gem". Manipura is often associated with the colors yellow, blue in classical tantra, and red in the Nath tradition. 

Manipura is associated with fire and the power of transformation. It is said to govern digestion and metabolism as the home of Agni and the vital wind Samana Vayu. The energies of Prana Vayu and Apana Vayu (inward and outward flowing energy) meet at the point in a balanced system.

Manipura is the home of the coeliac plexus, which innervates most of the digestive system. In chakra-based medicine, practitioners work this area to promote healthier digestion, elimination, pancreas-kidney and Adrenal function. Weak Agni (fire) in the coeliac plexus leads to incompletely digested food, thoughts and emotions, and is a source of ama (toxicity).

Manipura is represented with a downward-pointing red triangle, signifying the tattva of fire, within a bright yellow circle, with 10 dark-blue or black petals like heavily laden rain clouds.

The fire region is represented by the god Vahni, who is shining red, has four arms, holds a rosary and a spear. Vahni is making the gestures of granting boons, or favors, and dispelling fear. Agni is later referenced as well as Hinduism altered over time.

The seed mantra is the syllable 'ram'. Within the bindu, or dot, above this mantra resides the deity Rudra. He is red or white, with three eyes, of ancient aspect with a silver beard, and is smeared with white ashes. Rudra makes the gestures of granting boons and dispelling fear and is seated either on a tiger skin or a bull.

Rudra's Shakti is the goddess Lakini. She has a black or dark-blue vermilion color; has three faces, each with three eyes; and is four-armed. Lakini holds a thunderbolt, the arrow shot from the bow of Kama, and fire. She makes the gestures of granting boons and dispelling fear. Lakini is seated on a red lotus.

The ten petals of Manipura are dark-blue or black, like heavily laden rain clouds, with the syllables ḍaṁ, ḍhaṁ, ṇaṁ, taṁ, thaṁ, daṁ, dhaṁ, naṁ, paṁ, and phaṁ upon them in a dark-blue color. These petals correspond to the vrittis of spiritual ignorance, thirst, jealousy, treachery, shame, fear, disgust, delusion, foolishness and sadness.

The petals represent the ten Prānas (currents and energy vibrations) that are regulated by the Manipūra Chakra. The five Prāna Vayus are: Prāna, Apāna, Udāna, Samāna And Vyāna. The five Upa Prānas are: Nāga, Kūrma, Devadatta, Krikala and Dhananjaya.

The position of Manipura is stated as being behind the navel. Sometimes a secondary chakra called Surya (sun) chakra is located at the solar plexus, whose role is to absorb and assimilate Prana from the sun. Being related to the sense of sight, it is associated with the eyes, and being associated with movement, it is associated with the feet.

In the endocrine system, Manipura is said to be associated with the pancreas and the outer adrenal glands (the adrenal cortex). These glands create important hormones involved in digestion, converting food into energy for the body, in the same way that Manipura radiates Prana throughout the body.